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Aprea Therapeutics, Inc.
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Your Vote Counts! APREA THERAPEUTICS, INC. 2021 Annual Meeting to be held on June 9, 2021 Vote by June 8, 2021 11:59 PM ET APREA THERAPEUTICS, INC. 535 BOYLSTON STREET BOSTON, MA 02116 D52037-P56905 You invested in APREA THERAPEUTICS, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy materials for the stockholder meeting to be held on June 9, 2021. Get informed before you vote View the Notice, Proxy Statement and 2020 Annual Report online OR you can receive a free paper or email copy of the materials by requesting prior to May 26, 2021. If you would like to request a copy of the materials for this and/or future stockholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to firstname.lastname@example.org. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. Smartphone users Point your camera here and vote without entering a control number Vote Virtually During the Meeting June 9, 2021 9:00 A.M. Eastern Time Virtually at: www.virtualshareholdermeeting.com/APRE2021 V1 For complete information and to vote, visit www.ProxyVote.com Control #
Vote at www.ProxyVote.com THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming stockholder meeting. Please follow the instructions on the reverse side to vote these important matters. Board Recommends Voting Items D52038-P56905 Prefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click “Sign up for E-delivery”. 1. ELECTION OF TWO CLASS II DIRECTORS AND ONE CLASS I DIRECTOR 1a. Johan Christenson, M.D., Ph.D. (Class II) For 1b. Fouad Namouni, M.D. (Class II) For 1c. Richard Peters, M.D., Ph.D. (Class I) For 2. RATIFICATION OF APPOINTMENT OF ERNST & YOUNG LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR FISCAL YEAR 2021 For